![]() The Hospital Anxiety and Depression Scale (HADS) is a questionnaire developed to assess anxiety and depression in patients. A score of ≥4 was defined as severe fatigue. The final score was achieved by dividing the total score by the number of questions. Patients and control subjects were asked to rate 9 questions, each from 1 to 7, where 1 represented strong disagreement and 7 represented strong agreement. and was validated in the Turkish population by Armutlu et al. The Fatigue Severity Scale (FSS) was developed by Krupp et al. Healthy control subjects who were matched with age, sex, marital status, educational status, and body mass index (BMI) were also included for comparison. Subjects and MethodsīTm patients who were followed at the University of Health Sciences Istanbul Training and Research Hospital Hematology Clinic between 20 and had normal biochemical parameters, thyroid function tests and C-reactive protein levels, did not use any medications, consume alcohol or tobacco, and have any chronic diseases or sleep disturbances were included in the study. In this study, we aimed to investigate the association between BTm and fatigue, depression and anxiety. Likewise, data regarding the presence of fatigue and anxiety in adult BTm subjects are insufficient. Yet, studies including quality of life in BTm subjects are limited, and only depression was demonstrated to be frequent in individuals with BTm compared to the healthy population. Quality of life is influenced unfavorably, and the prevalence of either depression or anxiety is increased in BTM and BTI patients. ![]() While BTM and BTI patients are usually symptomatic with frequent blood transfusion requirements, individuals with BTm occasionally have a mild asymptomatic microcytic anemia, which is usually incidentally encountered. ![]() Beta thalassemias are divided into 3 groups according to the clinical and laboratory findings, which are beta thalassemia minor (BTm), beta thalassemia intermedia (BTI), and beta thalassemia major (BTM). As a result from this abnormal hemoglobin synthesis, hypochromic microcytic anemia might develop. Karger AG, Baselīeta thalassemias are a group of genetic blood disorders, characterized by disrupted and inadequate production of the beta-globin chains of hemoglobin, due to various mutations in the beta-globin genes. Conclusion: We found that both depression and anxiety were higher in BTm patients than in healthy individuals, but this difference was not feasible for fatigue. HADS anxiety score was ≥10 in 20 (51.3%) BTm subjects and in 5 (20.0%) control subjects ( p = 0.018), and HADS depression score was ≥7 in 20 (51.3%) BTm subjects and in 6 (24.0%) healthy control subjects ( p = 0.039).There was no correlation of hemoglobin with FSS score ( p = 0.526, r = –0.105), HADS anxiety score ( p = 0.703, r = –0.063), or HADS depression score ( p = 0.718, r = –0.06) in the BTm group. FSS score was ≥4 in 23 (59.0%) BTm subjects and in 15 (60%) control subjects ( p = 1.0). The BTm and the control groups were comparable in terms of gender, age, BMI, educational status and marital status ( p = 0.368, 0.755, 0.851, 0.785, and 0.709, respectively). Results: Thirty-nine BTm patients and 25 healthy controls were included in the study. ![]() Subjects and Methods: BTm patients who were followed at the University of Health Sciences Istanbul Training and Research Hospital Hematology Clinic between 20 and who had normal biochemical parameters, thyroid function tests and C-reactive protein levels, and did not use any medications, consume alcohol or tobacco, have any chronic diseases or sleep disturbances were included in the study. Objective: We aimed to investigate whether the severity of fatigue and the incidences of depression and anxiety of patients with beta thalassemia minor (BTm) are different from healthy individuals using the Fatigue Severity Scale (FSS) and Hospital Anxiety and Depression Scale (HADS).
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